Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study

BACKGROUND Inconsistent results have been obtained with regard to headache comorbidity in multiple sclerosis (MS). OBJECTIVE Investigate the one-year prevalence of migraine and tension-type headache (TTH) in Norwegian MS patients and relate this to clinical parameters. METHODS A questionnaire concerning headache was administered to 756 MS patients and 1090 controls and used to determine the one-year prevalence of migraine and frequent TTH. RESULTS No significant differences were seen between patients and controls or between patients with different disease course. Less migraine was observed in patients with Expanded Disability Status Scale score (EDSS) ≥4.0. CONCLUSIONS This case-control study does not support an association between migraine or TTH and MS.